United States securities and exchange commission logo October 27, 2022 Sizhen Wang Chief Executive Officer Genetron Holdings Limited 1-2/F, Building 11, Zone 1 No. 8 Life Science Parkway Changping District, Beijing, 102206 People s Republic of China Re: Genetron Holdings Limited Annual Report on Form 20-F Response dated September 30, 2022 File No. 001-39328 Dear Sizhen Wang: We have reviewed your September 30, 2022 response to our comment letter and have the following comment. In our comment, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this comment within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe our comment applies to your facts and circumstances, please tell us why in your response. After reviewing your response to this comment, we may have additional comments. Unless we note otherwise, our references to prior comments are to comments in our August 16, 2022 letter. Annual Report on Form 20-F Introduction, page iii 1. We note your response to prior comment 1. Please ensure that your disclosure in future reports clarifies that the legal and operation risks associated with operating in China also apply to operations in Hong Kong and/or Macau. To the extent you have operations in Hong Kong or Macau, please also ensure that you provide additional disclosure related to the enforceability of civil liabilities in these jurisdictions. You may contact Ibolya Ignat at 202-551-3636 or Angela Connell at 202-551-3426 if you have questions regarding comments on the financial statements and related matters. Please Sizhen Wang Genetron Holdings Limited October 27, 2022 Page 2 contact Alan Campbell at 202-551-4224 or Tim Buchmiller at 202-551-3635 with any other questions. Sincerely, FirstName LastNameSizhen Wang Division of Corporation Finance Office of Industrial Applications and Comapany NameGenetron Holdings Limited Services October 27, 2022 Page 2 cc: Xuelin Wang FirstName LastName